Quiznazoline-2,4(1 H,3 H)-diones are a very important structural sub-moiety of many commercially available drugs and biologically active molecules. 3–7 Nowadays, various transition metal (such as Pd 3, Cu 4, Ag 5, Co 6 and Ni 7) catalyzed reactions have been reported, where isocyanides are employed for the production of N-containing heterocyclic molecules. Isocyanides have been largely used as important synthons in modern synthetic organic chemistry, particularly for N-containing heterocyclic compounds synthesis via chemical conversions, including multi-component reactions. 1 Although a significant development has already been in progress in the related field, mainly by d-block metal-catalyzed reactions, the synthesis of heterocyclic compounds such as phenyl-annulated heteroarenes through carbon dioxide insertion has been less explored.
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Introduction In the last two decades, the scientific community has given increasing attention to the use of non-toxic, renewable, abundant, and inexpensive carbon dioxide for manufacturing value-based organic compounds. We have checked the recyclability of the catalyst, the results indicated that the catalyst maintained its catalytic efficacy even after six cycles of use. For the investigation of the mechanistic route of the catalytic reaction, density functional theory (DFT) calculations were also monitored. The catalyst is very efficient to produce the quinazoline derivatives. In this report, the formation of N3-substituted 2,4(1 H,3 H)-quinazolinediones was performed under mild and heterogeneous reaction conditions under 1 bar CO 2 pressure. The catalyst was characterized by FT-IR, XRD, ICP-AES, Raman spectroscopy, XPS, TEM, SEM, EDX, and N 2 absorption desorption studies. In this study, a heterogeneous catalyst was designed and synthesized from aminically modified graphene oxide by the incorporation of palladium metal. The chemical combination of atmospheric carbon dioxide, isocyanides, and 2-iodoaniline in a one-pot reaction for the synthesis of quinazoline-2,4(1 H,3 H)-dione derivatives is a straight forward and attractive methodology to avoid multi-step and more toxic reagent containing routes. In the current era, the scientific community is very much interested to utilize the greenhouse gas, carbon dioxide, through chemical fixation in order to produce value-based fine organic chemicals.